Cutting Edge: Structural Basis for the Recognition of b-Linked Glycolipid Antigens by Invariant NKT Cells
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منابع مشابه
Cutting edge: structural basis for the recognition of β-linked glycolipid antigens by invariant NKT cells.
Invariant NKT (iNKT) cells expressing a semi-invariant Vα14 TCR recognize self and foreign lipid Ags when presented by the nonclassical MHCI homolog CD1d. Whereas the majority of known iNKT cell Ags are characterized by the presence of a single α-linked sugar, mammalian self Ags are β-linked glycosphingolipids, posing the interesting question of how the semi-invariant TCR can bind to such struc...
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